In situ structure of the poxvirus portal complex

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10856-2Cryo-electron tomography uncovers the structure of a conserved hexameric ‘portal complex’ that spans the core wall in vaccinia virus, and shows how it is associated with viral functions such as assembly, mRNA release and genome uncoating.