Enzymatic glycosylation and amidation reshapes polyene bioactivity

Nature, Published online: 29 July 2026; doi:10.1038/s41586-026-10834-8Pathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and efficient fermentation and potential for safe use as antifungal treatments is described.